Platelet-specific chimeric 7E3 immunoglobulin
US5770198A · kind A · utility
136Cited by
9References
21Claims
0Family size
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Key dates
| Filing date | Jan 17, 1995 |
| Grant date | Jun 23, 1998 |
| Priority date | — |
| Expiry date | Jan 17, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Platelet-specific, chimeric immunoglobulin and immunoglobulin fragments are described. The chimeric molecules are made up of a nonhuman antigen binding region and a human constant region. Preferred immunoglobulins are specific for glycoprotein IIb/IIIa receptor in its complexed form; they block ligand binding to the receptor and prevent platelet aggregation. The immunoglobulins are useful in anti-thrombotic therapy when administered alone or in conjunction with thrombolytic agents, as well as in thrombus imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.