Long-chain alkylamides of amino acids and peptides with anti-proliferative and anti-inflammatory properties

US5770574A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Bernhard Kutscher · Maintal, DE
• Michael Bernd · Frankfurt, DE
• Heinz Grossmann · Regensburg, DE
• Maria Kick · Regensburg, DE
• Jurgen Arp · Regensburg, DE
• Manfred Lieflander · Sinzing, DE
• Jurgen Engel · Alzenau, DE
• Rainer Voegeli · Bielefeld, DE

Key dates

• Filing date: Jun 19, 1997
• Grant date: Jun 23, 1998
• Expiry date: Jun 19, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Long-chain, unbranched alkylamides of the general formula EQU CH.sub.3 --(CH.sub.2).sub.n N--NH--R in which n=11-20 and R=amino acid, its D- and L-enantiomers, di- and tripeptides, forms derived by N-protective groups, and terminal ethyl esters as well as its physiologically compatible salt forms as active pharmaceutical substances with anti-proliferative and anti-inflammatory properties.