Pyrrolinone-based peptidomimetics

US5770732A · kind A · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Ralph F. Hirschmann · La Cañada Flintridge, US
• Amos B. Smith, III · Yeadon, US
• Paul A. Sprengeler · San Diego, US
• Ryan Holcomb · Glen Rock, US
• Terence P. Keenan · Cambridge, US
• John L. Wood · Hamden, US
• Mark Guzman · Philadelphia, US
• Alexander Pasternak · Brookline, US

Key dates

• Filing date: Aug 2, 1994
• Grant date: Jun 23, 1998
• Expiry date: Aug 2, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/36
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.