Device and method for sampling of substances using alternating polarity
US5771890A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 24, 1994 |
| Grant date | Jun 30, 1998 |
| Priority date | — |
| Expiry date | Jun 24, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/14532
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one or more sampling chambers that function as both anode and cathode during the course of sa…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.