Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors

US5772992A · kind A · utility

Assignee

• G.D. Searle LLC · US

Inventors

• S. Christopher Bauer · New Haven, US
• Mark Allen Abrams · Chesterfield, US
• Sarah Ruth Braford-Goldberg · Chesterfield, US
• Maire Helena Caparon · Chesterfield, US
• Alan Michael Easton · Maryland Heights, US
• Barbara Kure Klein · Eureka, US
• John McKearn · Park Hills, US
• Peter O. Olins · Park Hills, US
• Kumnan Paik · Wilmette, US
• John Warren Thomas · Eureka, US

Key dates

• Filing date: Feb 4, 1994
• Grant date: Jun 30, 1998
• Expiry date: Feb 4, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions comprising a human interleukin-3 (hIL-3) variant or mutant protein (mutein) and another colony stimulating factor, cytokine, lymphokine, interleukin, or hematopoietic growth factor. The compositions are useful for the therapeutic co-administration of the proteins, as for example in hematopoietic reconstitution. factors or IL-3 variants.