Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5773001A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 3, 1994 |
| Grant date | Jun 30, 1998 |
| Priority date | — |
| Expiry date | Jun 3, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.