Regioselective .alpha.-hydrolysis of amino acid diesters using pig liver esterase
US5773261A · kind A · utility
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18Claims
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Key dates
| Filing date | Aug 26, 1996 |
| Grant date | Jun 30, 1998 |
| Priority date | — |
| Expiry date | Aug 26, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/14
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The regioselective and chemoselective hydrolysis of an .alpha.-ester group of an amino acid diester using pig liver esterase enzyme (PLE) is disclosed. The amino acid diesters may be either N-protected or unprotected and the diester groups may be the same or different. In particular, the preparation of a number of .gamma.-ester glutamates and .beta.-ester aspartates are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.