Synthetic matrix metalloprotease inhibitors and use thereof

US5773438A · kind A · utility

Assignees

• Glycomed Incorporated · US
• University of Florida Foundation, Incorporated · US

Inventors

• Daniel Levy · San Mateo, US
• Damian Wojciech Grobelny · Melbourne, AU
• Cho Tang · Moraga, US
• Kevin R. Holme · Alameda, US
• Richard E. Galardy · Lexington, US
• Gregory S. Schultz · Gainesville, US
• Asaad Nematalia · Alameda, US
• John H. Musser · Alameda, US

Key dates

• Filing date: Jun 5, 1994
• Grant date: Jun 30, 1998
• Expiry date: Jun 5, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, keratoconus, restenosis, rheumatoid arthritis, wounds, cancer, angiogenesis and shock.