Compounds for treating disorders of lipid metabolism and their preparation

US5773447A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gerhard Rackur · Idstein, DE
• Hans Georg Boger · Idstein, DE
• Norbert Krass · Frankfurt am Main, DE
• Axel Hoffmann · Berlin, DE
• Michael Leineweber · Frankfurt am Main, DE

Key dates

• Filing date: Jun 13, 1997
• Grant date: Jun 30, 1998
• Expiry date: Jun 13, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to tertiary 4-amino-2-ureidopyrimidine-5-carboxamides of formula I: ##STR1## in which R.sup.1 is (C.sub.1 -C.sub.8)-alkyl wherein one or more H are replaced by F; R.sup.2 is selected from the group consisting of F, Cl, Br, H, --O--(C.sub.1 -C.sub.8)-alkyl and (C.sub.1 -C.sub.8)-alkyl, wherein one or more of the H of the alkyls can be replaced by F; R.sup.3 is selected from the group consisting of F, Cl, Br, H, --O--(C.sub.1 -C.sub.4)-alkyl and (C.sub.1 -C.sub.4)-alkyl, wherein one or more of the H of the alkyl can be replaced by F; R.sup.4 is CF.sub.3 or OCF.sub.3 ; and their physiologically tolerable salts. Process for preparing the compounds of formula I are also described. The compounds are suitable for the treatment of disorders of lipid metabolism.