Potent inducers of terminal differentiation and method of use thereof

US5773474A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York and Sloan-Kettering Institute for Cancer Research · US

Inventors

• Ronald Breslow · Englewood, US
• Paul A. Marks · Washington, US
• Richard A. Rifkind · New York, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jun 30, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D243/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides a class of compounds and compositions thereof having the structure: ##STR1## wherein A is: ##STR2## The invention also concerns a method of selectively inducing terminal differentiation of neoplastic cells thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable conditions with an amount of the compound to selectively induce terminal differentiation. It also provides a method of treating a patient having a tumor characterized by proliferatoin of neoplastic cells comprising administration of an amount of the compound effective to inhibit proliferation and suppress oncogenicity of neoplastic cells.