Meta-substituted phenylene derivatives

US5773646A · kind A · utility

Assignee

• G.D. Searle LLC · US

Inventors

• Nizal Chandrakumar · North Grafton, US
• Barbara Chen · Braintree, US
• Helen Chen · Livingston, US
• Michael Clare · Skokie, US
• Alan F. Gasiecki · Vernon Hills, US
• Richard A. Haack · Chicago, US
• James W. Malecha · Libertyville, US
• Peter G. Ruminski · Ballwin, US
• Mark Russell · Skokie, US

Key dates

• Filing date: Mar 27, 1997
• Grant date: Jun 30, 1998
• Expiry date: Mar 27, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.