Rapidly dissolving dosage form

US5776491A · kind A · utility

Assignees

• The Board of Regents of the University of Oklahoma · US
• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Loyd V. Allen, Jr. · Edmond, US
• Bingnan Wang · Oklahoma City, US
• John Desmond Davies · Grosse Pointe Farms, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jul 7, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2063
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns a particulate support matrix, a solid dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into the oral cavity. First, a porous particulate powder which will serve as the tablet support matrix is produced. In the second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In the third step the mixture is formed into a tablet. Finally, in the fourth step, a coating may be applied to the outer surface of the tablet to enhance the intactness and durability of the tablet.