Process for preparing a clodronate preparation
US5776499A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 6, 1996 |
| Grant date | Jul 7, 1998 |
| Priority date | — |
| Expiry date | Aug 6, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The object of the invention is a process for preparing a clodronate preparation. The process is characterized in that clodronate is crystallized as disodium clodronate tetrahydrate from an aqueous solution of disodium clodronate; the resulting disodium clodronate tetrahydrate is dry granulated by compressing in such a way that the crystal structure of the disodium clodronate tetrahydrate is preserved and by crumbling and screening the mass to granules of a sutiable size, the dry granulated disodium clodronate tetrahydrate is optionally mixed with suitable excipients, such as filling agents and gliding agents and, if necessary, disintegrants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.