Method for peptide synthesis starting from N- (N'-nitrosocarbamoyl) amino acids

US5777076A · kind A · utility

Assignee

• Universite Montpellier II Sciences et Techniques du Languedoc · FR

Inventors

• Auguste Commeyras · Clapiers, FR
• Helene Collet · Montpellier, FR
• Louis Mion · Montpellier, FR
• Sylvie Benefice · Montpellier, FR
• Patrick Calas · Montpellier, FR
• Henri Choukroun · Clapiers, FR
• Jacques Taillades · Clapiers, FR
• Catherine Bied · Montpellier, FR

Key dates

• Filing date: May 19, 1997
• Grant date: Jul 7, 1998
• Expiry date: May 19, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K1/10
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method for peptide synthesis using an N-N'-nitroso-(R')carbamoyl!amino acid as the starting compound. The compound is separated into N.sub.2, R'OH and N-carboxyanhydride of formula (II). ##STR1## The compound (II) together with an amino acid or peptide with at least one free .alpha.-amino function is introduced into a reactive medium to obtain a dipeptide or a higher peptide than the added peptide.