Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
US5777123A · kind A · utility
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2References
5Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 27, 1997 |
| Grant date | Jul 7, 1998 |
| Priority date | — |
| Expiry date | Feb 27, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.