Process for preparing levobupivacaine and analogues thereof
US5777124A · kind A · utility
40Cited by
1References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 25, 1997 |
| Grant date | Jul 7, 1998 |
| Priority date | — |
| Expiry date | Apr 25, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing levobupivacaine, racemic bupivacaine or another N-alkyl analogue thereof, comprises chlorinating pipecolic acid hydrochloride, amidation of the resultant pipecolyl chloride hydrochloride in solvent, without isolation, with 2,6-dimethylaniline, and alkylation of the resultant pipecolic acid 2,6-xylidide. Alternatively, the alkylation may be followed by the amidation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.