Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions
US5777135A · kind A · utility
9Cited by
10References
10Claims
0Family size
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Key dates
| Filing date | Jul 31, 1995 |
| Grant date | Jul 7, 1998 |
| Priority date | — |
| Expiry date | Jul 31, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility are provided. Dioxetanes further instituted with two or more water-solubilizing groups disposed on the dioxetane structure provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. Compositions comprising a dioxetane with two or more water-solubilizing groups, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.