Liquid delivery compositions

US5780044A · kind A · utility

Assignee

• Atrix Laboratories, Inc. · US

Inventors

• Gerald L. Yewey · St. Augustine, US
• Nancy L. Krinick · Salt Lake City, US
• Richard L. Dunn · Fort Collins, US
• Michael Radomsky · Mountain View, US
• Gerbrand Brouwer · Menlo Park, US
• Arthur J. Tipton · Birmingham, US

Key dates

• Filing date: Dec 5, 1996
• Grant date: Jul 14, 1998
• Expiry date: Dec 5, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/918
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.