Composition for oral administration of peptides
US5780434A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 19, 1995 |
| Grant date | Jul 14, 1998 |
| Priority date | — |
| Expiry date | Sep 19, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/095
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A solid pharmaceutical composition for oral administration of small and medium size peptides, particularly vasopressin, oxytocin, and their analogues, comprises the peptide, a protease inhibitor, an enteric coat and a pharmaceutically acceptable carrier containing a buffering agent buffering at a pH of from 3 to 6, preferably about pH 5. A method of manufacture of single doses of the peptide comprises mixing of the ingredients, forming the resulting mixture into spheres smaller than 2 mm, coating the spheres with an enteric coat which is readily soluble in gastric juice of pH 5.0 or higher but not at substantially lower pH, and filling the coated spheres in capsules or incorporating them into tablets, degradable in the stomach. Also disclosed is a method for oral administration to a patient of the single dose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.