IL-8 receptor antagonists

US5780483A · kind A · utility

Assignee

• SmithKline Beecham Limited · US

Inventors

• Katherine L. Widdowson · King of Prussia, US
• Daniel F. Veber · Ambler, US
• Anthony Joseph Jurewicz · Royersford, US
• Robert Philip Hertzberg · Downingtown, US
• Melvin Clarence Rutledge, Jr. · Lansdale, US

Key dates

• Filing date: Aug 21, 1996
• Grant date: Jul 14, 1998
• Expiry date: Aug 21, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in treating chemokine mediated diseases wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (Ia) are represented by the structure: ##STR1## wherein interalia, X is oxygen or sulfur; PA1 Rb is NR.sub.6 R.sub.7, alkcyl, aryl, arylC.sub.1-4 alkyl, aryl C.sub.2-4 alkenyl, heteroaryl, heteroarylC.sub.1-4 alkyl, heteroarylC.sub.2-4 alkenyl, heterocyclic or heterocyclic C.sub.1-4 alkyl, or a heterocyclic C.sub.2-4 alkenyl moiety, camphor, all of which may be optionally substituted; PA1 R.sub.1 is independently selected from hydrogen; halogen; nitro; cyano; C.sub.1-10 alkyl; halosubstituted C.sub.1-10 alkyl; C.sub.2-10 alkoxy; halosubstituted C.sub.1-10 alkoxy; azide; (CR.sub.8 R.sub.8)q S(O).sub.t R.sub.4 ; hydroxy; hydroxy substituted C.sub.1-4 alkyl; aryl; aryl C.sub.1-4 alkyl; aryl C.sub.2-10 alkenyl; aryloxy; aryl C.sub.1-4 alkyloxy; heteroaryl; heteroarylalkyl; heteroaryl C.sub.2-10 alkenyl; heteroaryl C.sub.1-4 al…