Endothelin receptor antagonists
US5780498A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 30, 1996 |
| Grant date | Jul 14, 1998 |
| Priority date | — |
| Expiry date | Apr 30, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel compounds represented by the general formula I: ##STR1## wherein R.sub.1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a cycloalkyl, an aryl an aryl-cycloalkyl, lower alkoxy, an aryloxy, or a heteroaryl; PA0 R.sub.2 is hydrogen, a straight or branched lower alkyl, a cycloalkyl, or a cycloalkyl-lower alkyl; PA0 R.sub.3 and R.sub.3 ' are each the same or different and each is hydrogen atom, a straight or branched lower alkyl, a cycloalkyl, an aryl-lower alkyl, an aryl, or a heteroaryl; or PA0 R.sub.3 and R.sub.3 ' together form a ring structure; PA0 R.sub.3 " is hydrogen, lower alkyl or an aryl; or PA0 R.sub.2 and R.sub.3 " together form a lower alkylene group --(CH.sub.2).sub.n -- wherein n is an integer of 1, 2 or 3; or PA0 R.sub.2 and R.sub.3 " together form a group represented by the formula: --(CH.sub.2).sub.p --Ar-- or --Ar--(CH.sub.2).sub.p --, respectively, wherein p is zero or an integer of 1 or 2, and Ar is an arylene or heteroarylene; PA0 C(.dbd.X) is C(.dbd.O), C(.dbd.S), C(.dbd.NH), C(.dbd.N-lower alkyl); C.dbd.NH--OH, or CH.sub.2 ; PA0 Y is a direct bond, --NH--, a lower alkyl-N<, an oxygen ato…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.