Process for producing optically active benzhydrol compounds
US5780692A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 24, 1996 |
| Grant date | Jul 14, 1998 |
| Priority date | — |
| Expiry date | Dec 24, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C69/76
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for producing a benzhydrol compound (II) which comprises hydrogenating a benzophenone compound (I) in the presence of a hydrogenation catalyst consisting of a transition metal complex, a base and an optically active diamine compound: ##STR1## wherein R.sup.1 to R.sup.10 each represents H, OH, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkanoyl, etc., R.sup.2 and R.sup.3, and R.sup.8 and R.sup.9 may form --CH.dbd.CH--CH.dbd.CH--, or any two of R.sup.1 to R.sup.9 adjacent to each other may be bonded to thereby form --OCH.sub.2 O-- or --(CH.sub.2).sub.3 --. By using this process, optically active benzhydrol compounds which have a high purity and are useful as, for example, intermediates in the synthesis of drugs can be produced by simple procedures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.