Rigid bifunctional chelating agents
US5783169A · kind A · utility
3Cited by
10References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 26, 1995 |
| Grant date | Jul 21, 1998 |
| Priority date | — |
| Expiry date | Jul 26, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/1093
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bicyclo2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.