C-reactive protein fragment with immunomodulatory activity

US5783179A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• John J. Nestor · Cupertino, US
• Teresa H. Ho · Los Altos, US
• Deborah A. Eppstein · Palo Alto, US
• Philip Felgner · Rancho Santa Fe, US
• Barbara P. Barna · Berea, US
• Sharad D. Deodhar · Shaker Heights, US

Key dates

• Filing date: Aug 9, 1991
• Grant date: Jul 21, 1998
• Expiry date: Aug 9, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP), pharmaceutical compositions thereof, and methods of treating cancer with the compositions. Liposomal formulations containing the CRP-peptide fragment are particularly efficacious when administered in conjunction with interleukin-2.