Parathormone fragments, their preparation and medicaments containing these

US5783558A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Christian Duvos · Stade, DE
• Hubert Mayer · Braunschweig, DE
• Bernd Mueller-Beckmann · Grünstadt, DE
• Klaus Strein · Hemsbach, DE
• Edgar Wingender · Wolfenbüttel, DE

Key dates

• Filing date: Jul 20, 1994
• Grant date: Jul 21, 1998
• Expiry date: Jul 20, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns parathormone (PTH) fragments including the amino acid range of the natural parathormone of +3 to +35 and their physiologically compatible derivatives, a process for the preparation of the fragments according to the solid phase and liquid phase synthesis from partly blocked amino acids contained in the fragments which are coupled with one another in the sequence which corresponds to the amino acid sequence in the fragments to be prepared and medicaments containing at least one of the fragments, especially with calcium-regulating action in the body.