Stereoselective process for making substituted amino acid derivatives
US5783709A · kind A · utility
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2References
4Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 25, 1997 |
| Grant date | Jul 21, 1998 |
| Priority date | — |
| Expiry date | Aug 25, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention encompasses a method for the stereoselective synthesis of alkyl proline and other amino acid derivatives which are intermediates of the farnesyl-protein transferase inhibiting CA.sup.1 A.sup.2 X motif of the protein Ras. The instant process employs an efficient diastereoselective 2,3!-Wittig rearrangement of .alpha.-allyloxy amide enolates mediated by a chiral auxiliary to provide acyclic and cyclic precursors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.