Method and pharmaceutical and diagnosis compositions for drug targeting

US5785969A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Shlomo Magdassi · Jerusalem, IL
• Zichria Zazkay Rones · Jerusalem, IL
• Ofer Toledano · Kfar Sava, IL

Key dates

• Filing date: Jul 22, 1996
• Grant date: Jul 28, 1998
• Expiry date: Jul 22, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/927
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The new pharmaceutical and diagnostic compositions comprise antibody-aggregates and hydrophobic drug or marker molecules. The drug or marker molecules are solubilized inside micelle-like antibody-aggregates. In a process for preparing such types of compositions, hydrophobic residues are attached to the antibodies in the presence of a surface active agent. After removal of this agent the hydrophobic drug or marker molecules are solubilized inside the resulting antibody aggregates. A method for targeting molecules towards specific cells and sites within a living body is also disclosed.