Compositions and methods of manufacturing of oral dissolvable medicaments
US5785989A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 19, 1997 |
| Grant date | Jul 28, 1998 |
| Priority date | — |
| Expiry date | Mar 19, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61J7/003
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a carbohydrate, fat, protein, wax, or other dissolvable matrix composition. The dissolvable matrix may include permeation enhancers to increase the drug absorption by the mucosal tissues of the mouth. The matrix composition may also include p…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.