Hyperstabilizing antisense nucleic acid binding agents
US5786138A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 11, 1994 |
| Grant date | Jul 28, 1998 |
| Priority date | — |
| Expiry date | Aug 11, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3511
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Attaching certain ligands to antisense probes will hyperstabilize sense-antisense duplexes. Such a hyperstabilized duplex is resistant to melting of the strands from one another, to unwinding of the strands, and to the action of nucleases. Applications include antiretroviral action, anti-reverse-transcriptase action, antiviral action, antiparasitical action, antibacterial action, antifungal action, anticancer action, anti-oncogene action, and other applications where it is desired to inhibit gene expression at the genomic or messenger RNA level. The preferred ligands are certain minor-groove-binding agents, exemplified by CC-1065 and synthetic CC-1065 analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.