Target-selective protocols based on mimics
US5786336A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 1994 |
| Grant date | Jul 28, 1998 |
| Priority date | — |
| Expiry date | Sep 19, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91177
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method to potentiate the effect of a chemotherapeutic agent in a tumor cell, which method comprises administering to said tumor cell, along with said chemotherapeutic agent, a potentiating amount of a compound of the formula: ##STR1## or an amide, ester or hybrid amide/ester thereof, wherein X is a hydrocarbon radical optionally substituted on any aromatic moiety contained therein; Y--CO is .gamma.-Glu or .beta.-Asp and AA.sub.C is an amino acid, preferably glycine, phenylglycine, .beta.-alanine, alanine or phenylalanine is disclosed. Similar compounds can also be used to selectively exert cytotoxicity versus target cells as compared to nontarget cells and also to elevate the production of GM progenitors in bone marrow of mammalian subjects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.