Pyridazino-, pyrimido-, pyrazino- and triazinoindoles, -pyrrolocycloalkenes or pyrrolooxocycloalkenes, or pyridopyrrolylpyrido compounds, compositions containing them, and use thereof to treat atherosclerosis

US5786361A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Muller · Wuppertal, DE
• Peter Eckenberg · Wuppertal, DE
• Rudi Grutzmann · Solingen, DE
• Hilmar Bischoff · Wuppertal, DE
• Dirk Denzer · Wuppertal, DE
• Ulrich Nielsch · Wuppertal, DE

Key dates

• Filing date: Apr 11, 1997
• Grant date: Jul 28, 1998
• Expiry date: Apr 11, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with phenylglycinols. The compounds are suitable as active compounds in medicaments, in particular in medicaments having antiatherosclerotic activity.