VPA-analogous antiepileptics

US5786380A · kind A · utility

Inventors

• Heinz Nau · Berlin, DE
• Ursula Bojic · Berlin, DE
• Ralf-Siegbert Hauck · Berlin, DE
• Mohamed Mohey Eldin Elmazar · Shubra al Khayma, EG

Key dates

• Filing date: Nov 23, 1994
• Grant date: Jul 28, 1998
• Expiry date: Nov 23, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C57/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds which are effective antiepileptics and at the same time display only a slight sedative and teratogenic effect and have the formula ##STR1## where the compounds of the formulae (I) and (II) can also be mono- or polyunsaturated, in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each, independently of one another, hydrogen or a C.sub.1 -C.sub.6 -alkyl group, R.sup.5 is hydrogen or a C.sub.1 -C.sub.2 -alkyl group, and at least one of the radicals R.sup.1 to R.sup.4 in the compounds of the formulae (I) and (II) is different from hydrogen, where the compounds of the formula (I), in the case where a center of asymmetry is present on the carbon atom in position 2, and the compounds of the formulae (II), (III) and (IV) are in the form of their racemate, their pure enantiomers or a mixture of their enantiomers which differs from the racemate, and pharmaceutically compatible salts thereof.