Method of preventing formation of adhesions following surgery

US5786421A · kind A · utility

Assignee

• Cohesion Technologies, Inc. · US

Inventors

• Woonza M. Rhee · Palo Alto, US
• Prema R. Rao · Los Gatos, US
• George H. Chu · Sunnyvale, US
• Frank DeLustro · Belmont, US
• Carol F. H. Harner · Redwood Shores, US
• Naomi Sakai · San Mateo, US
• Jacqueline A. Schroeder · Redwood City, US

Key dates

• Filing date: May 6, 1997
• Grant date: Jul 28, 1998
• Expiry date: May 6, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S602/904
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.