N-alkyl and N-acyl derivatives of 3,7-Diazabicyclo-3.3.1!nonanes and selected salts thereof as multi-class antiarrhythmic agents

US5786481A · kind A · utility

Assignee

• THE BOARD OF REGENTS OF OKLAHOMA STATE UNIVERSITY · US

Inventors

• Kenneth D. Berlin · Stillwater, US
• Gregory Lynn Garrison · Chelmsford, US
• Subbiah Sangiah · Stillwater, US
• Cyril Clarke · Perkins, US
• Chun-Lin Chen · Taipei, TW
• Ralph Lazzara · Oklahoma City, US
• Benjamin J. Scherlag · Oklahoma City, US
• Eugene Patterson · Oklahoma City, US
• George Edward Burrows · Stillwater, US

Key dates

• Filing date: Oct 19, 1995
• Grant date: Jul 28, 1998
• Expiry date: Oct 19, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3,7-Diazabicyclo3.3!nonanes and selected derivatives thereof of the general formula: ##STR1## wherein Q=S; Z=CH.sub.2 ; and Y equals an N-acyl or N-alkyl group are disclosed as multiclass antiarrhythmic agents.