Racemization and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
US5786484A · kind A · utility
37Cited by
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18Claims
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Key dates
| Filing date | May 30, 1997 |
| Grant date | Jul 28, 1998 |
| Priority date | — |
| Expiry date | May 30, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B55/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the racemisation of an optically-enriched piperidine-2-carboxanilide compound, comprises heating the compound in the presence of an alkanoic or arylalkanoic acid. A process for the asymmetric transformation of such a compound comprises heating the compound in the presence of an acid as defined above, a chiral acid resolving agent and an inert cosolvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.