Methods for making concentrated plasma and/or tissue sealant
US5788662A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1996 |
| Grant date | Aug 4, 1998 |
| Priority date | — |
| Expiry date | Oct 22, 2016 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB04B2005/0478
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to stat preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods. Antifibrinolytic agents (such as aprotinin) are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient's blood. The tissue sealant also contains patient pla…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.