Endosomolytically active particles

US5789230A · kind A · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthew Cotten · Wien, AT
• Susanna Chiocca · Wien, AT
• Gotthold Schaffner · Littlehampton, AU
• Ernst-Werner Wagner · Langenzersdorf, AT

Key dates

• Filing date: Apr 12, 1996
• Grant date: Aug 4, 1998
• Expiry date: Apr 12, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/6901
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Endosomolytically active virus-like particle which is made up of units of capsid proteins of viruses or virus-like particles, the capsid protein units having a membrane-active peptide sequence. The particles are suitable as components of compositions for transporting nucleic acids into higher eukaryotic cells by receptor-mediated endocytosis.