Treatment of endotoxin-associated disorders with cationic peptides
US5789377A · kind A · utility
11Cited by
3References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 13, 1995 |
| Grant date | Aug 4, 1998 |
| Priority date | — |
| Expiry date | Mar 13, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/705
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.