Sialyl Lewis.sup.x mimetics containing phenyl backbones

US5789385A · kind A · utility

Assignee

• Glycomed Incorporated · US

Inventors

• Mark B. Anderson · Salt Lake City, US
• Daniel Levy · San Mateo, US
• Peng Cho Tang · Moraga, US
• John H. Musser · Alameda, US
• Narasinga Rao · Alameda, US
• Jing Rong Cui · Albany, US

Key dates

• Filing date: Feb 21, 1996
• Grant date: Aug 4, 1998
• Expiry date: Feb 21, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that possess selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or their mimics are separated by a linker that permits binding between those groups and the selecting, such compounds being represented by the following general structural formula I: ##STR1##