Substituted thiazolo 3,2-a!azepine derivatives
US5789403A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 11, 1996 |
| Grant date | Aug 4, 1998 |
| Priority date | — |
| Expiry date | Mar 11, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a substituted thiazolo3,2-a!azepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase. The above substituted thiazolo3,2-a!azepine derivative is represented by the following general formula (I): ##STR1## (wherein R1 represents a hydrogen atom or a protecting group of a thiol group; R2 represents a hydrogen atom, a lower alkyl group, an aryl group which may have a substituent, a hetroaryl group which may have a substituent, a lower alkoxyl group or a lower alkylthio group; R3, R4 and R5 may be the same or different from one another and represent each a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group or the like, with the proviso that the case wherein all of R3, R4 and R5 are hydrogen atoms are excepted; PA1 R6 and R7 may be the same or different from each other and represent each a hydrogen atom or a lower alkyl group; R8 represents a hydrogen atom or a protecting group of a carboxyl group; and PA1 m and m are each independently 0 or, 1 or 2).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.