Piperazides derived from arylpiperazine, processes for their preparation, their use as medicaments and pharmaceutical compositions comprising them
US5789412A · kind A · utility
54Cited by
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38Claims
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Key dates
| Filing date | Jan 20, 1997 |
| Grant date | Aug 4, 1998 |
| Priority date | — |
| Expiry date | Jan 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D319/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 5HT receptor antagonists of general formula (I) ##STR1## in which Ar.sub.1 and Ar.sub.2 are aromatic residues, X is O, NH, CH.sub.2 O, or CH.sub.2 NH, and R.sub.1 is hydrogen or linear or branched alkyl comprising 1-6 carbon atoms, as well as their salts, hydrates, solvates, and physiologically-acceptable bioprecursors for their therapeutic use, their geometric and optical isomers, and their mixtures in all proportions and in racemic form, methods for the preparation of these novel antagonists, and their use in the treatment of a living animal and pharmaceutical compositions comprising them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.