Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

US5789434A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Harold C. Kluender · Madison, US
• Guenter Hans Herbert Heinz Benz · Velbert, DE
• David R. Brittelli · Branford, US
• William Bullock · Easton, US
• Kerry Combs · Wallingford, US
• Brian R. Dixon · Woodbridge, US
• Stephan Schneider · Wuppertal, DE
• Jill Wood · Hampton, US
• Michael C. VanZandt · Guilford, US
• Donald J. Wolanin · Orange, US
• Scott Wilhelm · Orange, US

Key dates

• Filing date: Nov 6, 1995
• Grant date: Aug 4, 1998
• Expiry date: Nov 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each T represents a substituent group; x is 0, 1, or 2; D represents ##STR2## .delta. is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then .delta.=0, and when U' is O or S, then .delta.=1; R.sup.14 is any of a variety of substituent groups; and G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, R.sup.11 represents H or an alkyl group, R.sup.12 represents an alkyl group, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.