Guanine analog phosphates
US5789589A · kind A · utility
2Cited by
6References
16Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 22, 1996 |
| Grant date | Aug 4, 1998 |
| Priority date | — |
| Expiry date | Apr 22, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65616
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are novel prodrugs represented by the following structural formulas: ##STR1## Z is oxygen or sulfur; n is 1 or 2; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a group which can be metabolized in vivo to a give a modified A such that the phosphoester bond (modified A)--O undergoes cleavage in vivo. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.