Process for preparing 1-substituted 8-chloro-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester compounds

US5789591A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Daniel Chu · Santa Clara, US
• David A. DeGoey · Salem, US
• David J. Grampovnik · Waukegan, US
• Larry L. Klein · Lake Forest, US
• Paul A. Lartey · Waukegan, US
• Christina L. Leone · Kenosha, US
• Sheela A. Thomas · Libertyville, US
• Ming C. Yeung · Grayslake, US

Key dates

• Filing date: Oct 23, 1996
• Grant date: Aug 4, 1998
• Expiry date: Oct 23, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D455/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing a compound having the formula: ##STR1## wherein R is selected from the group consisting of C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkylmethyl, C.sub.1 -C.sub.6 -alkyl, allyl and 2-methoxyethyl, by reacting: ##STR2## under defined conditions with subsequent stepwise reactions of the respective intermediate compounds with a malonic acid diester, POCl.sub.3, and by heating the final intermediate in a high boiling solvent.