Labeled chemotactic peptides to image focal sites of infection or inflammation

US5792444A · kind A · utility

Assignees

• The General Hospital Corporation · US
• Johnson Matthey Inc. · GB
• Ortho Pharmaceutical Corporation · US

Inventors

• Alan J. Fischman · Boston, US
• Howard F. Solomon · New Hope, US
• Claudia K. Derian · Hatboro, US
• Gary Bridger · Bellingham, US
• John D. Higgins, III · Whitemarsh, US
• Scott K. Larsen · Boston, US
• Pedro E. Hernandez · Malvern, US
• Robert H. Rubin · Brookline, US
• H. William Strauss · Redwood City, US
• Anthony J. Fuccello · Princeton, US
• Daniel Kroon · Bound Brook, US

Key dates

• Filing date: Oct 22, 1993
• Grant date: Aug 11, 1998
• Expiry date: Oct 22, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure EQU X--Y--Leu--Phe--Z!.sub.n --W wherein: PA1 X is an amino protecting group, PA1 Y is an amino acid residue, PA1 Z is a spacer sequence, PA1 n is 0 or 1, and PA1 W is a labeling or attachment substituent.