Isolated DNA encoding novel protease inhibitory polypeptide
US5792629A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1994 |
| Grant date | Aug 11, 1998 |
| Priority date | — |
| Expiry date | Aug 19, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/37
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a novel polypeptide which comprises an amino acid sequence that constitutes a portion of urinary trypsin inhibitor (UTI) and which has no antigenicity against human and high activity to inhibit various proteases, as well as other novel polypeptides having excellent activities to inhibit various proteases obtained by mutation of the former novel polypeptide. This invention also provides novel enzyme inhibition processes, drug compositions and treating methods making use of the novel polypeptide, DNA fragments containing nucleotide sequences which encode the novel polypeptides, vectors containing the DNA fragments and transformants transformed with the DNA fragments or the vectors, as well as processes for the production of the novel polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.