Targeting protein-diagnostic/therapeutic agent conjugates having Schiff base linkages
US5795560A · kind A · utility
17Cited by
0References
7Claims
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Assignee
Inventor
Key dates
| Filing date | May 16, 1996 |
| Grant date | Aug 18, 1998 |
| Priority date | — |
| Expiry date | May 16, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Targeting protein-diagnostic/therapeutic agent conjugates joined by stabilized Schiff base linkages are disclosed. Schiff base linkage of targeting protein and agent is accomplished without exposure of the targeting protein to harsh oxidizing or reducing conditions. The cleavable, heterobifunctional linkers that are described provide certain advantages relating to in vivo administration of targeting protein conjugates, including controlled release of active agent at a target site.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.