Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5795876A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 25, 1997 |
| Grant date | Aug 18, 1998 |
| Priority date | — |
| Expiry date | Mar 25, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/695
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods useful for inhibiting VCAM-1 and for treating chronic inflammatory conditions in a patient in need thereof are disclosed comprising administering to the patient effective amounts of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group; PA1 Z is a thio, oxy or methylene group; PA1 A is a C.sub.1 -C.sub.4 alkylene group; PA1 R.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl; are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.