Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient
US5795891A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 8, 1996 |
| Grant date | Aug 18, 1998 |
| Priority date | — |
| Expiry date | Feb 8, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C259/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for diseases caused by an increased collagenase activity containing the same as the active ingredient, wherein R.sup.1 represents hydrogen atom, methyl, methylaminomethyl or morpholinomethyl; R.sup.2 represents hydrogen atom, hydroxy, fluorine atom, or C.sub.1 -C.sub.4 linear or branched alkyl; and R.sup.3 represents C.sub.1 -C.sub.4 linear or branched alkyl. The compound (I) and the salt maintains a potent collagenase inhibitor activity in the blood for long after being administered, and are useful as a remedy for various diseases believed to be caused by an increased collagenase activity. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.