4-aminopyridazines, method of preparing them and drugs containing these compounds

US5795892A · kind A · utility

Assignee

• Boehringer Mannhelm GmbH · DE

Inventors

• Wolfgang von der Saal · Rosenheim, DE
• Reinhard Heck · Oftersheim, DE
• Ralf Kucznierz · Bad Dürkheim, DE
• Herbert Leinert · Heppenheim, DE
• Karlheinz Stegmeier · Heppenheim, DE

Key dates

• Filing date: Feb 28, 1997
• Grant date: Aug 18, 1998
• Expiry date: Feb 28, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns new 4-aminopyridazines of the general formula I ##STR1## in which R.sup.1 denotes an R.sup.2 --SO.sub.2 --O-- or R.sup.2 --SO.sub.2 --NR.sup.3 -- group in which PA1 R.sup.2 denotes a cycloalkyl residue, an unsubstituted or substituted aryl or heteroaryl residue, PA1 R.sup.3 denotes a hydrogen atom, an alkyl or alkyloxyalkyl group which can be unsubstituted or substituted once or several times by hydroxy groups wherein the hydroxy groups can be substituted by alkyl, hydroxyalkyl, alkyloxyalkyl, hydroxyalkyloxyalkyl or alkylcarbonyl groups and wherein in each case two vicinal hydroxy groups can be linked together by alkylidene groups, as well as hydrates, solvates and physiologically tolerated salts thereof. The invention also concerns the optically active forms, racemates and mixtures of diastereomers of these compounds, processes for their production and pharmaceutical agents containing these compounds having a thrombin-inhibiting action.